A vital part of the biotechnology sector is the cell and gene supply chain, which handles the manufacturing and transfer of valuable biological resources including cells, genes, and other macromolecules. Cell banks, biomanufacturers, distributors, and research institutes are just a few of the many parties involved in the supply chain that collaborate to guarantee the availability, safety, and quality of these biological resources. The effectiveness of products, patient care, and public health might all be impacted by supply chain interruptions since it is intricate and susceptible to them. The industry is implementing cutting-edge technologies like blockchain, digital twins, and artificial intelligence to reduce these risks and increase supply chain resilience, visibility, and predictability.